On Tuesday, January 1, 2013, of Upper St. Clair, peacefully with her loving family by her side. Isabel was born in Rices Landing, PA to the late John Edward O'Laughlin and Sarah Frances (Collins) O'Laughlin. She was a graduate of Cumberland Township High School. In addition to her parents, Isabel was preceded in death by her daughter, Amy; a brother, John E. O'Laughlin, Jr.; and a sister, Woneta Shipley. Isabel is the beloved wife of 55 years to Joseph S. DeSantis; dear mother of Thomas S. (Shelley) DeSantis, D.M.D., Anne Louise DeSantis, John J. (Colleen) DeSantis, and Matthew J. (Julia) DeSantis; loving Nanny to Daniel, Emily, Patrick, Lauren, Michael, and Martin DeSantis; and siblings, Frank (Mary) O'Laughlin, Joseph (Shelby) O'Laughlin, and Anna Marie (John) Semonik, all of Cleveland, OH. She is also survived by numerous nieces and nephews. Funeral arrangements by BEINHAUERS. 724-941-3211. Friends welcome at 2828 Washington Road, McMurray, 15317, from 2-4 and 6-8 on Friday. A Mass of Christian Burial will be celebrated at 10:00 on Saturday at Saint Thomas More, 126 Fort Couch Road, Pittsburgh, 15241. Interment will follow at Queen of Heaven Cemetery. In lieu of flowers, memorial donations in Isabel's name may be made to Saint Thomas More Parish. Please add or view Tributes at:
Send condolences at

Published in Pittsburgh Post-Gazette from Jan. 3 to Jan. 4, 2013