Tony passed away peacefully at home in Belmont, California with his loving wife, Elsie, at his side. He is survived by his second wife and professional partner Elsie Eugui, his two sons in the UK, Miles and Joseph Mark; and a half sister, Colleen, and half brother Roy who live in South Africa. Tony was part of a large family with numerous nieces, nephews, cousins, and friends living in different countries.
Tony was born in South Africa and grew up on his father's chrysanthemum farm Mawingo in upper Gilgil, Kenya. He went to boarding school and obtained his first university degree in South Africa, a B.Sc. in Medical Science at Witwatersrand University. In 1947 Tony went on to Merton College, Oxford. Life in post war England was very different from that in Africa. The winter of 1947-8 was the coldest in living memory, with the River Thames frozen, a climate not of Tony's liking.
Tony obtained his D.Phil with a medical qualification in 1952. For two years after obtaining his medical qualification, Tony worked at the Radcliffe Infirmary, Oxford. Most of 1953, however, was spent in East Africa doing the research for which he is best known, a demonstration that humans carrying the sickle cell trait are relatively resistant to Plasmodium falciparum malaria. He published three papers on this subject in 1954, and those are now considered classical references representing the first recognized example of Darwinian selection in humans.
After his East African sojourn, Tony completed postgraduate studies at the California Institute of Technology in the laboratory of Prof. Linus Pauling, the Nobel prize-winning chemist. It was then Tony realised that California has a better climate than England - a fact that he remembered well!
In spite of the weather, Tony returned to England, where he taught medicine at Oxford for three years. During that period, Tony married orientalist Helen Green, and his two sons, Miles and Joseph Mark were born. Tony and the boys' mother, Helen, later divorced. Miles is now a leading Gastroenterologist in Wales. Joseph Mark also lives in the U.K.
One of the visiting scientists in Tony's laboratory in London was a talented Argentinian biochemist, Elsie Eugui, whose upbringing and professional background aligned with Tony's. They soon found that they shared many interests and worked well together. Thus began a long and productive partnership, and they married some years later.
In 1978, Tony accepted a position in Nairobi, Kenya as Director of the International Laboratory for Research on Animal Diseases (ILRAD). Simultaneously he had an appointment at the World Health Organisation's (WHO) Immunology Laboratory in Nairobi. Immunity to malaria was being studied in the WHO lab, and Trypanosomes were being studied in both. Trypanosomes, transmitted by tsetse flies, limited good production of cattle in many parts of Africa, and caused sleeping sickness in humans. Elsie researched another parasitic disease of cattle, East Coast Fever, and she discovered the main mechanism of immunity to the causing parasite.
In 1981, Tony was recruited to be Vice President for Research at Syntex Corporation, Palo Alto, California. Syntex, with its reputation for excellent research, was an ideal environment to work on the development of Tony's concept of a novel immunosuppressive drug. In collaboration with Elsie and many other scientists, the successful development and widespread use of CellCept has dramatically improved the long-term survival of patients with transplanted organs. It is also commonly used in other immune diseases such as systemic lupus. CellCept went on to become one of Roche's blockbuster drugs.
Syntex was eventually acquired by Hoffman LaRoche, from which Tony retired in 1994. He continued to consult, lecture in human genetics at Stanford University and researched on several new therapeutic programs at Alavita Pharmaceuticals. Tony was editor or co-editor, of 12 books and author or co-author of more than 400 papers in peer-reviewed scientific journals. For two decades, his were among the top 100 most frequently cited papers in the world of bio-medical sciences, and for five years in the top 10. He received many awards for his work on malaria and immunosuppressive therapies.
Tony and Elsie have lived in their aerie in Belmont, overlooking San Francisco Bay, for over 30 years. They shared many interests outside work and both were docents and guides at Filoli Gardens and Edgewood Park. An avid reader with an extraordinary memory, Tony enjoyed classical music and was a frequent visitor to San Francisco art galleries. Tony was passionate about deep-sea fishing, hiking, bird-watching, and wine tasting, all of which he shared with Elsie and imparted to his sons.
A true gentleman, Tony will be sorely missed and remembered by friends, collaborators, and family for his boundless intellectual energy, his creativity, his many contributions to science, his work ethic, and his human qualities.
A celebration of his life will be held on April 13. Time and location will be available on the mortuary website www.crippenflynn.com or through Elsie at [email protected] . In lieu of flowers, the family suggests donations to be made to Doctors Without Borders, the Sierra Club, or any charity desired.
To plant trees in memory, please visit the Sympathy Store.
Peter and Patricia Wood
March 18, 2014
Tony's passing brings us back to a visit of Elsie and Tony to Vancouver some twenty-odd years ago. It was the beginning of a relationship that meant so very much to us over the years.
Soon we were visiting Belmont, Mexico, Argentina and California with reciprocal visits to Nevada City, Vancouver and Victoria. Tony and Elsie were the epitome of the perfect hosts, which turned into a friendship that we shall cherish for the rest of our lives.
Tony's scientific achievements, many partnered with Elsie, have been recorded elsewhere in his obituary. Our comments will record the times shared with a remarkably talented and generous couple.
Tony's range of interests were wide and deep. From being a very knowledgeable ornithologist and botanist he also had a love for deep-sea fishing. He also had a wide ranging interest in literature and a love of classical music.
Tony was never dull, his wit was genuine and most amusing and rarely, if ever, impinged on the acerbic. He had a love of cooking; with Tony and Elsie in the kitchen, the menus and wines carefully chosen, there were some famous dinners we have enjoyed.
Bridge was the only game that Tony would perhaps mark down as tolerably good. To a great degree, Tony was shy in demeanor but never timorous. His was truly a full life; he welcomed his research and continued to do remarkable work until the very end of his life. Also he enjoyed his docent work, visits to the theatre, opera, ballet and so forth.
Tony for all the years we knew him had the good fortune of being supported in so many of his adventures by Elsie, an equal partner and a great lady.
Requiescat in pace.
Peter Wood and Patricia Kongshavn
Beckie Underwood
March 11, 2014
Wow Elsie, what and amazing life you and Tony have led.
I am so sorry to hear of your loss, I know how difficult that is with their presence everywhere to remind us, but we no longer have their physical presence to touch & talk with.
Honor your grief, give it the time it needs to lessen the loss.
Paul Raju
March 11, 2014
My heartfelt condolences on the loss of a good mentor, friend and a great scientist - Paul A. Raju, Pacifica, CA
Ron Barnes
March 7, 2014
Elsie: my deepest sympathy.
Tony had the office next to me at Northwick Park. A Great Guy. A great loss.
HANS SOLLINGER
March 6, 2014
Dear Elsie, I will never forget what Tony did for my career.I wish I had met him earlier in his life he had so much teach.Still remember the delightful trip through Napa Valley.
Paul Freiman
March 6, 2014
My deepest sympathy. Tony was always bright,interesting and determined in his years at Syntex. I always enjoyed his company.
Paul Freiman
March 5, 2014
My deepest sympathy to the family: May you find comfort in knowing that ALMIGHTY GOD, friends and family are with you at this time of sadness.
Denise
March 4, 2014
My condolences to the family. May the joyful memories of your loved one sustain you and may the God of Peace comfort you.
Monica Harewood
March 2, 2014
My deepest sympathy for your loss.
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