John Fredrick Hughes

1948 - 2025

John Fredrick Hughes, 77, resident of Greenwood and loving husband of Cindy Benjamin Hughes, passed away on Wednesday, December 10, 2025 at Self Regional Medical Center.

Born in Latta SC, he was a son of the late Frederick Shuler and Sallie Norton Hughes. A graduate of Latta High School and the University of South Carolina School of Pharmacy, John then moved to Greenwood in 1972 to work for Self Memorial Hospital as Pharmacy Director. He continued his Pharmacy career in retail until his retirement in 2018. John was active in the Greenwood community, serving as a former director and co-director of the South Carolina Festival of Flowers, and he was also an active member of the Greenwood Sertoma Club. In addition, he was a faithful member of the Episcopal Church of the Resurrection. Dedicated to his calling as a Pharmacist, John was the recipient of the Bowl of Hygeia in Pharmacy in 1985 and was awarded Pharmacist of the year by the Index Journal for five consecutive years. Of all his accomplishments, John was most proud of his family.

Surviving in addition to his wife of the home to cherish his memory are his children Jaime Hughes of Latta, Erick Hughes (Becca) of Greenwood, Shirley Campbell (David) of Abbeville, Glenn Yonce (Gail) of Greenwood, Lee Yonce (Devin), of Charlotte NC, Timothy Yonce (Hannah) of Charlotte NC, Tricia Yonce (David), Robyn Griffin (Mike), Ginny Bratcher (Jay), and Tammy Tallman, all of Greenwood. He is also survived by grandchildren Alexys Hughes, Ronnie Hughes, Summer Yonce, (Heath), Christopher, Carly, and Cameryn Campbell, Victoria and James Bratcher, Serenity Stevens, Georgianna Yonce, Tanner Griffin, Austin Griffin (Anna), Alexis Gamble, Eliana Rodriguez, Caleb Rios, Marshall Tallman, Hayley Rillon (Adrian), Allison Hayes, Desiree (Jacob) White, Kyndel and Haily Dean, Bruce Wade, Jr. and DeMontae Wade; and great-grandchildren Liam and Brantley Phillips, Atlas, Melody, and Meadow Rillon, Clinton Griffin and Azele White. He is also survived by his brother Norton S. Hughes (Lynn) of Latta, and nephew Shuler Hughes.

Memorial services will be conducted 3:00 PM Sunday, December 21 at the Episcopal Church of the Resurrection with Rev. Mary Balfour Van Zandt officiating.

The family will receive friends at the church from 2:00PM to 3:00PM Sunday afternoon.

Memorials may be made to the Episcopal Church of the Resurrection, PO Box 3283, Greenwood, SC 29648 or to the Humane Society Greenwood, PO Box 49776, Greenwood, SC 29649, or to the charity of one's choice.

For online condolences please visit www.blythfuneralhome.com.

Blyth Funeral Home & Cremation Services is assisting the Hughes family.