Gregory Scott Smith passed away on December 27, 2025, at his home in Virginia with his wife by his side. He was 70 years old.
Greg was the son of Oney Percy Smith, M.D., and Gloria Tetrault Smith and brother to Tracey Lauren Smith, all of whom predeceased him. He is survived by his wife Regina “Gina” Quigley; his sister Sharron Close and husband Lanny of Atlanta, GA; his brother Oney Smith and wife Marcia of Fredrick, MD; and his stepmother Lucy Merrow of Ossipee, NH.
Greg grew up in Latham, NY, and graduated from Christian Brothers Academy before earning his bachelor’s degree at LeMoyne College where he met his wife, Gina. Greg received his master’s and Ph.D. of Physiology/Cell Biology from the University of Texas Graduate School of Biomedical Sciences at the University of Texas Health Sciences Center in Houston.
After earning his Ph.D., Greg worked for a short time at the Texas Medical Center as an Assistant Professor of Surgery and Pathology & Laboratory Medicine at UTHSCH. He later relocated to St. Louis, where he spent the majority of his professional career teaching at St. Louis University Medical School. Greg was a tenured Professor of Surgery at SLU, where he also served in Assistant Dean roles for Student Affairs and Educational Development. Greg was a dedicated teacher of surgery and was beloved by his medical students, who honored him five times with the prestigious Golden Apple Award for his profound impact on medical students. He stayed in touch with many of his students after their graduations and derived endless joy hearing about their many professional and personal accomplishments.
One of Greg’s greatest sources of pride and joy was Jatinder Gosal, M.D., a pediatric emergency medical physician whom he loved and considered his daughter. Jatinder and her husband, Sukhpreet, are from Phoenix, AZ, and recently blessed Greg with a grandchild, Harghun.
Greg immersed himself in new hobbies and interests often. He was an avid coin collector, enjoyed fishing, loved music and playing the guitar, collected antique slot machines, and hand-crafted beautiful pens for family and friends. A recent interest of Greg’s was receiving tattoos, which he wore proudly. He and Gina shared a passion for traveling to the Caribbean, always first class!
Greg and Gina retired to the Lake Monticello community of Palmyra, VA, to be back on the East Coast and closer to family and friends. Greg made great friends along his journey – from growing up in Latham and spending lots of time with the Devito family, enjoying summers in Wells, ME, with his father and siblings, college life at LeMoyne, and working at SLU. These friendships and memories remained with him the rest of his life. He also enjoyed time with new “coffee friends” and neighbors at the lake where they shared many stories and lots of humor.
Greg deeply loved all his dogs that shared his life - Beau Beau, Cheyenne, Bugsy, Jesse and of course his and Gina’s current dog, Doc, whom he adored. Greg believed strongly in rescuing animals.
No formal service is planned, honoring Greg’s wishes. Donations in his memory can be made to an animal rescue organization; the Fluvanna Habitat for Humanity, located in Palmyra, VA; or a favorite charitable organization.
To plant trees in memory, please visit the Sympathy Store.
4626 Cedar Lane Road, Kents Store, VA 23084
Please consider a donation as requested by the family.

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